New model of Oral Mucositis with 5-Fluorouracil chemo-induced in Wistar rats without the use of anesthesics

ABSTRACT Introduction: Oral mucositis (OM) is considered the most frequent acute side effect of antineoplasic treatment, with ulcerative lesions resulting from a painful symptomatology, affecting oral cavity in response to Antineoplastic treatment. In order study these effects, experiments animal models are necessary, using antineoplastic drugs for induction OM and anesthetics, mainly Ketamine Xylazine, perform scarification cheeks. Objective: The goal report an experimental model induced OM, without use anesthetics stage Methods: Fourty five male Wistar rats, 7 weeks old weighting 220g, were used, divided into 2 groups; by 5-Fluorouracil intraperitoneal administration. Two days later, Group I was physically contained, contrast, II anesthetized focusing on irritating cheek mucosa tip sterile needle, potentialize development OM. animals euthanized anesthetic overdose. Results: Concerning experiment chemo-induced where irritation performed physical containment, (Ketamine Xylazine), had longer survivability rapid improvement effects chemotherapy. Conclusion: This new promising, considering that Xylazine) showed high mortality rate. absence anesthesia, all survived until end involving chemotherapy restraint.